The use of hyperspectral imaging is a fast growing field with many applications in the civilian, commercial and military sectors. Hyperspectral images are typically composed of many spectral bands in the visible and infrared regions of the electromagnetic spectrum and have the potential to deliver a great deal of information about a remotely sensed scene. One area of interest regarding hyperspectral images is anomaly detection, or the ability to find spectral outliers within a complex background in a scene with no a priori information about the scene or its specific contents. Anomaly detectors typically operate by creating a statistical background model of a hyperspectral image and measuring anomalies as image pixels that do not conform properly to that given model. In this study we compare the performance over diurnal and seasonal changes for several different anomaly detection methods found in the literature and a new anomaly detector that we refer to as the fuzzy cluster-based anomaly detector. Here we also compare the performance of several anomaly-based change detection algorithms. Our results indicate that all anomaly detectors tested in this experimentation exhibit strong performance under optimum illumination and environmental conditions. However, our results point toward a significant performance advantage for cluster-based anomaly detectors in the presence of adverse environmental conditions.