Lop Nur, as the center of China and Eurasia, has a special position in geoscience research. The objective of this paper is to give a comprehensive and reasonable explanation of how the unique Lop Nur Ear feature formed. Because of the severe natural environment, the extensive area, and the difficult field work conditions, remote sensing data are highly suitable for the study of the Lop Nur lake basin. Three types of multisource remote sensing data are applied in this study. Combined with field investigations and laboratory measurements, the causes of the “Ear” feature are explored from different points of view. The results indicate that surface roughness is the most direct cause, while the salinity and depth of the subsurface dry medium layer are the root causes, and topography is an important environmental factor for the formation of the Lop Nur Ear feature. The results of this study help to solve a geological mystery and also provide a new insight into climate change and the demise of ancient civilizations.