Detection of small trace molecules in human and animal exhalation by tunable diode lasers for applications in biochemistry and medical diagnostics

Eugene V. Stepanov; Andrian I. Kouznetsov; Pavel V. Zyrianov; Vladimir A. Skrupskii; Yurii A. Shulagin; Marina E. Galagan

doi:10.1117/12.201243

10 February 1995 Detection of small trace molecules in human and animal exhalation by tunable diode lasers for applications in biochemistry and medical diagnostics

Eugene V. Stepanov, Andrian I. Kouznetsov, Pavel V. Zyrianov, Vladimir A. Skrupskii, Yurii A. Shulagin, Marina E. Galagan

Author Affiliations +

Proceedings Volume 2331, Medical Sensors II and Fiber Optic Sensors; (1995) https://doi.org/10.1117/12.201243
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

Tunable diode laser spectroscopy (TDLS) is proposed for content measurements of trace gases like CO, CO₂, NH₃, CH₄, NO, NO₂ in human and animal exhalation. High sensitivity and wide dynamic range of the method ensure fast detection of these gases at ppb level and within the accuracy better than 10%. One-expiration sample is enough to reach these parameters. There is no need for any preliminary preparations of tested samples. Some pairs of the gases, for instance, CO and CO₂, NH₃ and CO₂ and CO and N₂O, can be measured simultaneously by one laser providing complex studies. The high sensitive gas analysis could provide necessary background to the noninvasive diagnostics in a wide variety of medical problems. Perspectives of the TDLS methods in application to medicine diagnostics are demonstrated by the first results of exhalation tests.

Citation Download Citation

Eugene V. Stepanov, Andrian I. Kouznetsov, Pavel V. Zyrianov, Vladimir A. Skrupskii, Yurii A. Shulagin, and Marina E. Galagan "Detection of small trace molecules in human and animal exhalation by tunable diode lasers for applications in biochemistry and medical diagnostics", Proc. SPIE 2331, Medical Sensors II and Fiber Optic Sensors, (10 February 1995); https://doi.org/10.1117/12.201243

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available