Adrenergic mechanism responsible for pathological alteration in gastric mucosal blood flow in rats with ulcer bleeding

O. V. Semyachkina-Glushkovskaya; A. N. Pavlov; I. A. Semyachkin-Glushkovskiy; A. S. Gekalyuk; M. V. Ulanova; V. V. Lychagov; V. V. Tuchin

doi:10.1117/12.2068824

17 September 2014 Adrenergic mechanism responsible for pathological alteration in gastric mucosal blood flow in rats with ulcer bleeding

O. V. Semyachkina-Glushkovskaya, A. N. Pavlov, I. A. Semyachkin-Glushkovskiy, A. S. Gekalyuk, M. V. Ulanova, V. V. Lychagov, V. V. Tuchin

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Proceedings Volume 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014); 92300H (2014) https://doi.org/10.1117/12.2068824
Event: Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 2014, Wuhan, China

Abstract

The adrenergic system plays an important role in regulation of central and peripheral circulation in normal state and during hemorrhage. Because the impaired gastric mucosal blood flow (GMBF) is the major cause of gastroduodenal lesions, including ulcer bleeding (UB), we studied the adrenergic mechanism responsible for regulation of GMBF in rats with a model of stress-induced UB (SUB) using the laser Doppler flowmetry (LDF). First, we examined the effect of adrenaline on GMBF in rats under normal state and during UB. In all healthy animals the submucosal adrenaline injection caused a decrease in local GMBF. During UB the submucosal injection of adrenaline was accompanied by less pronounced GMBF suppression in 30,3% rats with SUB vs. healthy ones. In 69,7% rats with SUB we observed the increase in local GMBF after submucosal injection of adrenaline. Second, we studied the sensitivity of gastric β2-adrenoreceptors and the activity of two factors which are involved in β2-adrenomediated vasorelaxation-K_ATP -channels and NO. The effects of submucosal injection of isoproterenol, ICI118551 and glybenclamide on GMBF as well as NO levels in gastric tissue were significantly elevated in rats with SUB vs. healthy rats. Thus, our results indicate that high activation of gastric β2-adrenoreceptors associated with the increased vascular K_ATP -channels activity and elevated NO production is the important adrenergic mechanism implicated in the pathogenesis of UB.

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O. V. Semyachkina-Glushkovskaya, A. N. Pavlov, I. A. Semyachkin-Glushkovskiy, A. S. Gekalyuk, M. V. Ulanova, V. V. Lychagov, and V. V. Tuchin "Adrenergic mechanism responsible for pathological alteration in gastric mucosal blood flow in rats with ulcer bleeding", Proc. SPIE 9230, Twelfth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2014), 92300H (17 September 2014); https://doi.org/10.1117/12.2068824

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KEYWORDS

Stomach

Blood circulation

Tissues

Doppler effect

Endoscopy

Tissue optics

Animal model studies

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