Quantifying age-related changes in the structure and mechanical function of skin with multiscale imaging

Alan E. Woessner; Jake D. Jones; Nathan J. Witt; Edward A. Sander; Kyle P. Quinn

doi:10.1117/12.2610110

7 March 2022 Quantifying age-related changes in the structure and mechanical function of skin with multiscale imaging

Alan E. Woessner, Jake D. Jones, Nathan J. Witt, Edward A. Sander, Kyle P. Quinn

Proceedings Volume PC11944, Multiscale Imaging and Spectroscopy III; PC119440K (2022) https://doi.org/10.1117/12.2610110
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Second-harmonic generation microscopy and macro-scale imaging were combined to enable multiscale assessments of mouse skin undergoing uniaxial mechanical testing. Skin from old and young mice experienced a substantial micro-scale volume reduction during uniaxial tension. A non-affine relationship between the 3D collagen fiber kinematics and local deformation was also observed. Aged skin was found to have a lower stiffness but increased collagen fiber realignment during mechanical loading. These results are being used to develop multiscale models of skin mechanics and obtain a more complete understanding of age-related changes in skin structure-function relationships.

Conference Presentation

Citation Download Citation

Alan E. Woessner, Jake D. Jones, Nathan J. Witt, Edward A. Sander, and Kyle P. Quinn "Quantifying age-related changes in the structure and mechanical function of skin with multiscale imaging", Proc. SPIE PC11944, Multiscale Imaging and Spectroscopy III, PC119440K (7 March 2022); https://doi.org/10.1117/12.2610110

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