Optical metabolic imaging reveals differences in radiation resistant and susceptible tumor xenografts

Jesse D. Ivers; Sina Dadgar; Joel Rodriguez Troncoso; Narasimhan Rajaram

doi:10.1117/12.2650384

17 March 2023 Optical metabolic imaging reveals differences in radiation resistant and susceptible tumor xenografts

Jesse D. Ivers, Sina Dadgar, Joel Rodriguez Troncoso, Narasimhan Rajaram

Proceedings Volume PC12363, Multiscale Imaging and Spectroscopy IV; PC123630I (2023) https://doi.org/10.1117/12.2650384
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Multi-photon microscopy was used to determine the differential response to radiation at multiple time points between radiation-resistant and -susceptible human head and neck cancer tumor xenografts grown in a cohort of 60 athymic mice. Mice were randomly divided into groups for cell line, treatment or control, and time points relative to treatment — baseline, 1 hour-, 24 hours-, and 48 hours-post-treatment. We quantified the optical redox ratio, lifetime of NAD(P)H, and heterogeneity in ORR and lifetime endpoints. We saw a significant effect of cell line, treatment, and the interaction of all three factors — line, treatment, and time point.

Conference Presentation

Citation Download Citation

Jesse D. Ivers, Sina Dadgar, Joel Rodriguez Troncoso, and Narasimhan Rajaram "Optical metabolic imaging reveals differences in radiation resistant and susceptible tumor xenografts", Proc. SPIE PC12363, Multiscale Imaging and Spectroscopy IV, PC123630I (17 March 2023); https://doi.org/10.1117/12.2650384

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