Optical coherence elastography detects changes in corneal stiffness due to LASIK in ex vivo porcine cornea

Achuth Nair; Fernando Zvietcovich; Manmohan Singh; Mitchell Weikert; Salavat Aglyamov; Kirill Larin

doi:10.1117/12.3000545

13 March 2024 Optical coherence elastography detects changes in corneal stiffness due to LASIK in ex vivo porcine cornea

Achuth Nair, Fernando Zvietcovich, Manmohan Singh, Mitchell Weikert, Salavat Aglyamov, Kirill Larin

Author Affiliations +

Proceedings Volume PC12824, Ophthalmic Technologies XXXIV; PC128240O (2024) https://doi.org/10.1117/12.3000545
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

The biomechanical properties of the cornea are tightly linked to its structure. Refractive procedures, including laser assisted in situ keratomileusis (LASIK), can be used to correct myopia and hyperopia through precision alteration of corneal structure. However, structural alterations undoubtedly have consequences for its biomechanical integrity. Here, we utilize optical coherence elastography (OCE) to evaluate changes in corneal biomechanical properties after LASIK in ex vivo porcine corneas using three techniques, air coupled ultrasound OCE (ACUS-OCE), heartbeat OCE (Hb-OCE), and compression OCE. The results suggest that LASIK reduces tissue stiffness. Future work will examine stiffness changes in vivo.

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Citation Download Citation

Achuth Nair, Fernando Zvietcovich, Manmohan Singh, Mitchell Weikert, Salavat Aglyamov, and Kirill Larin "Optical coherence elastography detects changes in corneal stiffness due to LASIK in ex vivo porcine cornea", Proc. SPIE PC12824, Ophthalmic Technologies XXXIV, PC128240O (13 March 2024); https://doi.org/10.1117/12.3000545

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