In-vivo characterization of scleral rigidity in myopia patient based on the measurement of fundus pulsatile motion using phase sensitive optical coherence tomography

Zhaoyu Gong; Karine D. Bojikian; Andrew Chen; Philip P. Chen; Kasra A. Rezaei; Lisa C. Olmos; Raghu C. Mudumbar; Jonathan Li; Daniel M. Schwartz; Ruikang K. Wang

doi:10.1117/12.3005699

13 March 2024 In-vivo characterization of scleral rigidity in myopia patient based on the measurement of fundus pulsatile motion using phase sensitive optical coherence tomography

Zhaoyu Gong, Karine D. Bojikian, Andrew Chen, Philip P. Chen, Kasra A. Rezaei, Lisa C. Olmos, Raghu C. Mudumbar, Jonathan Li, Daniel M. Schwartz, Ruikang K. Wang

Author Affiliations +

Proceedings Volume PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; PC128302C (2024) https://doi.org/10.1117/12.3005699
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Myopia is a major cause of visual impairment worldwide. A reduction in scleral rigidity is hypothesized as an effective biomarker of degenerative myopia. However, no current technique is able to characterize posterior rigidity in-vivo and non-invasively. We present a novel methodology using phase-sensitive optical coherence tomography (PhS-OCT) to measure scleral rigidity. The rigidity is reflected by the magnitude of pulsatile fundus motion that is measured by PhS-OCT. A preliminary clinical experiment confirmed our methodology. Our findings can offer potential new diagnostic methods for degenerative myopia and related diseases, as well as applications for evaluating therapies that alter scleral mechanical properties.

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Zhaoyu Gong, Karine D. Bojikian, Andrew Chen, Philip P. Chen, Kasra A. Rezaei, Lisa C. Olmos, Raghu C. Mudumbar, Jonathan Li, Daniel M. Schwartz, and Ruikang K. Wang "In-vivo characterization of scleral rigidity in myopia patient based on the measurement of fundus pulsatile motion using phase sensitive optical coherence tomography", Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC128302C (13 March 2024); https://doi.org/10.1117/12.3005699

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