Skin cancer margin detection using nanosensitive optical coherence tomography and a comparative study with confocal microscopy

Rajib Dey; Martin Leahy; Sergey Alexandrov; Jack Kelly; Sine Phelan; Peter Owens

doi:10.1117/12.3006509

13 March 2024 Skin cancer margin detection using nanosensitive optical coherence tomography and a comparative study with confocal microscopy

Rajib Dey, Martin Leahy, Sergey Alexandrov, Jack Kelly, Sine Phelan, Peter Owens

Author Affiliations +

Proceedings Volume PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI; PC1284105 (2024) https://doi.org/10.1117/12.3006509
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

It is well known that many cancers have their first manifestations at the nanoscale. There is a clinical need for technologies which are sensitive to sub-surface tissue structural changes at the nanoscale, since the most troubling developments in cells and the extracellular matrix occur at this level. In the present study we investigate the usefulness of the nsOCT technique in the assessment and discrimination between healthy skin and cancer margin tissue by comparing information obtained from OCT imaging with high-resolution confocal microscopy image and the gold standard of histological examination of resected surgical specimens.

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Rajib Dey, Martin Leahy, Sergey Alexandrov, Jack Kelly, Sine Phelan, and Peter Owens "Skin cancer margin detection using nanosensitive optical coherence tomography and a comparative study with confocal microscopy", Proc. SPIE PC12841, Dynamics and Fluctuations in Biomedical Photonics XXI, PC1284105 (13 March 2024); https://doi.org/10.1117/12.3006509

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KEYWORDS

Skin cancer

Optical coherence tomography

Cancer detection

Confocal microscopy

Cancer

Biopsy

Diagnostics

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