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13 March 2024 Near-infrared II laser augments cancer immunotherapy
Shinya Yokomizo, Yoshifumi Kimizuka, Dmitriy N. Atochin, Satoshi Kashiwagi
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Proceedings Volume PC12843, Biophotonics and Immune Responses XIX; PC1284302 (2024) https://doi.org/10.1117/12.3002992
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Photobiomodulation (PBM) using near-infrared (NIR)-II light has been shown to enhance anti-cancer immunity by reducing oxidative stress, promoting proliferation, and reducing PD-1 expression in tumor-infiltrating CD8+ T cells, ultimately suppressing tumor progression. Meanwhile, photoimmunotherapy (PIT) using NIR light has also shown promise in cancer treatment, inducing a strong anti-cancer immune response. Combining PBM with laser-based phototherapy, including PIT, could have the potential to amplify their therapeutic effects maximally, offering a promising avenue for developing safe and effective cancer therapies.
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Shinya Yokomizo, Yoshifumi Kimizuka, Dmitriy N. Atochin, and Satoshi Kashiwagi "Near-infrared II laser augments cancer immunotherapy", Proc. SPIE PC12843, Biophotonics and Immune Responses XIX, PC1284302 (13 March 2024); https://doi.org/10.1117/12.3002992
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KEYWORDS
Cancer
Therapeutics
Cell death
Laser development
Laser therapeutics
Photodynamic therapy
Phototherapy
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