Near-infrared light of 1270 nm as a novel vaccine adjuvant acts on mitochondrial photoreception in intradermal vaccines

Yohei Maki M.D.; Toshihiro Kushibiki; Tomoya Sano; Eri Komai; Etsuko Kitagami; Takunori Ogawa M.D.; Shusaku Takahashi; Shinya Yokomizo; Miya Ishihara; Satoshi Kashiwagi; Akihiko Kawana; Yoshifumi Kimizuka

doi:10.1117/12.2688365

13 March 2024 Near-infrared light of 1270 nm as a novel vaccine adjuvant acts on mitochondrial photoreception in intradermal vaccines

Yohei Maki M.D., Toshihiro Kushibiki, Tomoya Sano, Eri Komai, Etsuko Kitagami, Takunori Ogawa M.D., Shusaku Takahashi, Shinya Yokomizo, Miya Ishihara, Satoshi Kashiwagi, Akihiko Kawana, Yoshifumi Kimizuka

Author Affiliations +

Proceedings Volume PC12843, Biophotonics and Immune Responses XIX; PC1284303 (2024) https://doi.org/10.1117/12.2688365
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We investigated the “laser adjuvant” that improved vaccine efficacy, via combining non-invasive near-infrared red (NIR) light irradiation and intradermal influenza vaccine and discovered the crucial role of reactive oxygen species (ROS) and mast cells. This study elucidates the effects of a new wavelength (1270 nm) of NIR light that exhibits a similar adjuvant effect at lower energy on mast cells and mouse skin, revealing ROS and ATP production via mitochondrial photoreception, increased chemokine mRNA expression, and durable antibody titers in immunized mice. These findings highlight the clinical potential of 1270 nm NIR light, demonstrating the wavelength-specific effect of laser adjuvants.

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Yohei Maki M.D., Toshihiro Kushibiki, Tomoya Sano, Eri Komai, Etsuko Kitagami, Takunori Ogawa M.D., Shusaku Takahashi, Shinya Yokomizo, Miya Ishihara, Satoshi Kashiwagi, Akihiko Kawana, and Yoshifumi Kimizuka "Near-infrared light of 1270 nm as a novel vaccine adjuvant acts on mitochondrial photoreception in intradermal vaccines", Proc. SPIE PC12843, Biophotonics and Immune Responses XIX, PC1284303 (13 March 2024); https://doi.org/10.1117/12.2688365

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