TIDBIT: portable diagnostics of multiplexed nutrition deficiencies: iron, vitamin A and inflammation status (Conference Presentation)

Zhengda Lu; David Erickson

doi:10.1117/12.2251243

19 April 2017 TIDBIT: portable diagnostics of multiplexed nutrition deficiencies: iron, vitamin A and inflammation status (Conference Presentation)

Zhengda Lu, David Erickson

Author Affiliations +

Proceedings Volume 10055, Optics and Biophotonics in Low-Resource Settings III; 1005504 (2017) https://doi.org/10.1117/12.2251243
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

Vitamin A and iron deficiency are common malnutrition affecting billions of people worldwide. However, in infrastructure limited settings, access to blood vitamin A and iron status test is limited because of the complexity and cost of traditional diagnostic methods. Direct measurements of vitamin A and iron level is not easy to perform, and it is necessary to measure approximate marker for obtaining vitamin A and iron deficiency status. Measurement of inflammatory marker is also necessary because the vitamin A and iron level are altered by inflammation status. Here we introduced a multiplex rapid point-of-care (POC) diagnostic devices that simultaneously characterize three markers relevant to vitamin A, iron and inflammation status: retinol binding protein 4, ferritin and C-reactive protein with lateral flow immunoassay test strips. Level of retinol binding protein 4, ferritin and C-reactive protein are indicated by excitation intensity of fluorescence tags with three different colors. The test can be done within 15 minutes and a complete sample-answer quantitative results of vitamin A, iron and inflammation status level can be obtained with assists of a smartphone and an external device. We also demonstrated the device is able to perform colorimetric analysis on single test area. which gives the device potential to perform more tests simultaneously at the same time.

Conference Presentation

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Zhengda Lu and David Erickson "TIDBIT: portable diagnostics of multiplexed nutrition deficiencies: iron, vitamin A and inflammation status (Conference Presentation)", Proc. SPIE 10055, Optics and Biophotonics in Low-Resource Settings III, 1005504 (19 April 2017); https://doi.org/10.1117/12.2251243

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KEYWORDS

Iron

Inflammation

Diagnostics

Proteins

Multiplexing

Point-of-care devices

Analytical research

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