CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 10056 > Article
Presentation
20 April 2017 Visibility of solid and liquid fiducial markers used for image-guided radiation therapy on optical coherence tomography: an esophageal phantom study (Conference Presentation)
Pouya Jelvehgaran, Tanja Alderliesten, Jelmer J. A. Weda, Daniel M. de Bruin, Dirk J. Faber, Maarten C.C. M. Hulshof M.D., Ton G. van Leeuwen, Marcel B. van Herk, Johannes F. de Boer
Author Affiliations +
Proceedings Volume 10056, Design and Quality for Biomedical Technologies X; 100560B (2017) https://doi.org/10.1117/12.2250911
Event: SPIE BiOS, 2017, San Francisco, California, United States
Abstract
Radiation therapy (RT) is used in operable and inoperable esophageal cancer patients. Endoscopic ultrasound-guided fiducial marker placement allows improved translation of the disease extent on endoscopy to computed tomography (CT) images used for RT planning and enables image-guided RT. However, microscopic tumor extent at the time of RT planning is unknown. Endoscopic optical coherence tomography (OCT) is a high-resolution (10-30µm) imaging modality with the potential for accurately determining the longitudinal disease extent. Visibility of fiducial markers on OCT is crucial for integrating OCT findings with the RT planning CT. We investigated the visibility on OCT (NinePoint Medical, Inc.) of 13 commercially available solid (Visicoil, Gold Anchor, Flexicoil, Polymark, and QLRAD) and liquid (BioXmark, Lipiodol, and Hydrogel) fiducial markers of different diameter. We designed and manufactured a set of dedicated Silicone-based esophageal phantoms to perform imaging in a controlled environment. The esophageal phantoms consist of several layers with different TiO2 concentrations to simulate the scattering properties of a typical healthy human esophagus. Markers were placed at various depths (0.5, 1.1, 2.0, and 3.0mm). OCT imaging allowed detection of all fiducial markers and phantom layers. The signal to background ratio was 6-fold higher for the solid fiducial markers than the liquid fiducial markers, yet OCT was capable of visualizing all 13 fiducial markers at all investigated depths. We conclude that RT fiducial markers can be visualized with OCT. This allows integration of OCT findings with CT for image-guided RT.
Conference Presentation
© (2017) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Pouya Jelvehgaran, Tanja Alderliesten, Jelmer J. A. Weda, Daniel M. de Bruin, Dirk J. Faber, Maarten C.C. M. Hulshof M.D., Ton G. van Leeuwen, Marcel B. van Herk, and Johannes F. de Boer "Visibility of solid and liquid fiducial markers used for image-guided radiation therapy on optical coherence tomography: an esophageal phantom study (Conference Presentation)", Proc. SPIE 10056, Design and Quality for Biomedical Technologies X, 100560B (20 April 2017); https://doi.org/10.1117/12.2250911
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Optical coherence tomography
Computed tomography
Liquids
Solids
Visibility
Endoscopy
Radiotherapy
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top