Baseline oxygen saturation comparison between pathologic complete responders and extensive residual cancer cases in response to neoadjuvant chemotherapy

Mirella L. Altoe; Jacqueline E. Gunther; Emerson Lim; Hyun Keol Kim; Jessica Campbell; Hanina Hibshoosh; Katherine Crew; Kevin Kalinsky; Dawn L. Hershman; Andreas H. Hielscher

doi:10.1117/12.2251452

17 February 2017 Baseline oxygen saturation comparison between pathologic complete responders and extensive residual cancer cases in response to neoadjuvant chemotherapy

Mirella L. Altoe, Jacqueline E. Gunther, Emerson Lim, Hyun Keol Kim, Jessica Campbell, Hanina Hibshoosh, Katherine Crew, Kevin Kalinsky, Dawn L. Hershman, Andreas H. Hielscher

Author Affiliations +

Proceedings Volume 10059, Optical Tomography and Spectroscopy of Tissue XII; 100590Q (2017) https://doi.org/10.1117/12.2251452
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

In this retrospective cohort study, we examine the hypothesis that baseline oxygen saturation (SO₂%) in contralateral normal tissue can be a quantitative measurement for predicting tumor response to neoadjuvant chemotherapy (NAC). Using our dynamic custom-built dual breast dynamic diffuse optical tomography (DOT) imager, we reconstructed SO₂% measurement concentration for 12 stage II or III breast cancer patients. Six patients achieved pCR (RCB-0) and the other half had extensive residual disease (RCB-III). Baseline SO₂% in contralateral normal tissue was statistically significantly higher in RCB-III subjects than in pCR (p = 0.025). From ROC analyses, baseline SO₂% in contralateral normal breast tissue was able to discriminate pCR from RCB-III patients (AUC 0.889) with sensitivity and specificity of 83%.

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Mirella L. Altoe, Jacqueline E. Gunther, Emerson Lim, Hyun Keol Kim, Jessica Campbell, Hanina Hibshoosh, Katherine Crew, Kevin Kalinsky, Dawn L. Hershman, and Andreas H. Hielscher "Baseline oxygen saturation comparison between pathologic complete responders and extensive residual cancer cases in response to neoadjuvant chemotherapy", Proc. SPIE 10059, Optical Tomography and Spectroscopy of Tissue XII, 100590Q (17 February 2017); https://doi.org/10.1117/12.2251452

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