A novel thermal accelerant for augmentation of microwave energy during image-guided tumor ablation

William K. C. Park; Aaron W. P. Maxwell; Victoria E. Frank; Michael P. Primmer; Jarod B. Paul; Cynthia Susai; Scott A. Collins; Tiffany M. Borjeson; Greyson L. Baird; Kara A. Lombardo; Damian E. Dupuy M.D.

doi:10.1117/12.2249772

22 February 2017 A novel thermal accelerant for augmentation of microwave energy during image-guided tumor ablation

William K. C. Park, Aaron W. P. Maxwell, Victoria E. Frank, Michael P. Primmer, Jarod B. Paul, Cynthia Susai, Scott A. Collins, Tiffany M. Borjeson, Greyson L. Baird, Kara A. Lombardo, Damian E. Dupuy M.D.

Author Affiliations +

Proceedings Volume 10066, Energy-based Treatment of Tissue and Assessment IX; 1006602 (2017) https://doi.org/10.1117/12.2249772
Event: SPIE BiOS, 2017, San Francisco, California, United States

Abstract

The greatest challenge in image-guided thermal ablation (IGTA) of liver tumors is a relatively high recurrence rate (ca. 30%) due to incomplete ablation. To meet this challenge, we have developed a novel Thermal Accelerator (TA) to demonstrate its capability to, 1) augment microwave (MW) energy from a distance unattainable by antenna alone; 2) turn into a gel at body temperature; 3) act as a CT or US contrast. We have examined the TA efficiency using in vitro and ex vivo models: microwave power, TA dose, frequencies and TA-to-tip distance were varied, and temperature readings compared with and without TA. Using the in vitro model, it was established that both the rate and magnitude of increase in ablation zone temperature were significantly greater with TA under all tested conditions (p<0.0001). On ultrasound imaging, the TA was echogenic as gel. On CT, TA density was proportional to dose, with average values ranging from 329 HU to 3071 HU at 10 mg/mL and 1,000mg/mL, respectively. TA can be accurately deposited to a target area using CT or US as image-guidance and augment MW energy effectively so that ablation time is significantly reduced, which will contribute to complete ablation. The preliminary results obtained from in vivo experiments using swine as an animal model are consistent with the observations made in in vitro and en vivo studies.

Citation Download Citation

William K. C. Park, Aaron W. P. Maxwell, Victoria E. Frank, Michael P. Primmer, Jarod B. Paul, Cynthia Susai, Scott A. Collins, Tiffany M. Borjeson, Greyson L. Baird, Kara A. Lombardo, and Damian E. Dupuy M.D. "A novel thermal accelerant for augmentation of microwave energy during image-guided tumor ablation", Proc. SPIE 10066, Energy-based Treatment of Tissue and Assessment IX, 1006602 (22 February 2017); https://doi.org/10.1117/12.2249772

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
9 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Microwave radiation

Antennas

Tumors

In vitro testing

Medium wave

Polymers

Computed tomography

Show All Keywords

Keywords/Phrases

Search In:

Publication Years