Numerical study on simultaneous emission and transmission tomography in the MRI framework

Lars Gjesteby; Wenxiang Cong; Ge Wang

doi:10.1117/12.2272505

19 September 2017 Numerical study on simultaneous emission and transmission tomography in the MRI framework

Lars Gjesteby, Wenxiang Cong, Ge Wang

Proceedings Volume 10391, Developments in X-Ray Tomography XI; 103910F (2017) https://doi.org/10.1117/12.2272505
Event: SPIE Optical Engineering + Applications, 2017, San Diego, California, United States

Abstract

Multi-modality imaging methods are instrumental for advanced diagnosis and therapy. Specifically, a hybrid system that combines computed tomography (CT), nuclear imaging, and magnetic resonance imaging (MRI) will be a Holy Grail of medical imaging, delivering complementary structural/morphological, functional, and molecular information for precision medicine. A novel imaging method was recently demonstrated that takes advantage of radiotracer polarization to combine MRI principles with nuclear imaging. This approach allows the concentration of a polarized Υ-ray emitting radioisotope to be imaged with MRI resolution potentially outperforming the standard nuclear imaging mode at a sensitivity significantly higher than that of MRI. In our work, we propose to acquire MRI-modulated nuclear data for simultaneous image reconstruction of both emission and transmission parameters, suggesting the potential for simultaneous CT-SPECT-MRI. The synchronized diverse datasets allow excellent spatiotemporal registration and unique insight into physiological and pathological features. Here we describe the methodology involving the system design with emphasis on the formulation for tomographic images, even when significant radiotracer signals are limited to a region of interest (ROI). Initial numerical results demonstrate the feasibility of our approach for reconstructing concentration and attenuation images through a head phantom with various radio-labeled ROIs. Additional considerations regarding the radioisotope characteristics are also discussed.

Conference Presentation

Citation Download Citation

Lars Gjesteby, Wenxiang Cong, and Ge Wang "Numerical study on simultaneous emission and transmission tomography in the MRI framework", Proc. SPIE 10391, Developments in X-Ray Tomography XI, 103910F (19 September 2017); https://doi.org/10.1117/12.2272505

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