Cell division is coupled to the optical redox ratio (Conference Presentation)

Rupsa Datta; Zhaoqi Li; Allison Lau; Matthew Vander Heiden; Melissa C. Skala

doi:10.1117/12.2289514

15 March 2018 Cell division is coupled to the optical redox ratio (Conference Presentation)

Rupsa Datta, Zhaoqi Li, Allison Lau, Matthew Vander Heiden, Melissa C. Skala

Proceedings Volume 10504, Biophysics, Biology and Biophotonics III: the Crossroads; 1050405 (2018) https://doi.org/10.1117/12.2289514
Event: SPIE BiOS, 2018, San Francisco, California, United States

Abstract

The cell cycle is extensively characterized, yet there is much to learn about the decision-making process involved in cell division. Here, the optical redox ratio (ratio of NADH to FAD fluorescence intensity) of MCF10A cells was imaged every 20 minutes over 12 hours using multiphoton microscopy. Cell tracking was used to monitor individual cells over time. We found a positive correlation in the variations of the optical redox ratio with the phases of the entire cell cycle. This study reveals the novel role of redox signaling in the progression the cell cycle.

Conference Presentation

Citation Download Citation

Rupsa Datta, Zhaoqi Li, Allison Lau, Matthew Vander Heiden, and Melissa C. Skala "Cell division is coupled to the optical redox ratio (Conference Presentation)", Proc. SPIE 10504, Biophysics, Biology and Biophotonics III: the Crossroads, 1050405 (15 March 2018); https://doi.org/10.1117/12.2289514

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available