Development of a diamond waveguide sensor for sensitive protein analysis using IR quantum cascade lasers

P. Piron; E. Vargas Catalan; J. Haas; L. Österlund; F. Nikolajeff; P. O. Andersson; J. Bergström; B. Mizaikoff; M. Karlsson

doi:10.1117/12.2289844

22 February 2018 Development of a diamond waveguide sensor for sensitive protein analysis using IR quantum cascade lasers

P. Piron, E. Vargas Catalan, J. Haas, L. Österlund, F. Nikolajeff, P. O. Andersson, J. Bergström, B. Mizaikoff, M. Karlsson

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Proceedings Volume 10539, Photonic Instrumentation Engineering V; 105390F (2018) https://doi.org/10.1117/12.2289844
Event: SPIE OPTO, 2018, San Francisco, California, United States

Abstract

Microfabricated diamond waveguides, between 5 and 20 μm thick, manufactured by chemical vapor deposition of diamond, followed by standard lithographic techniques and inductively coupled plasma etching of diamond, are used as bio-chemical sensors in the mid infrared domain: 5-11 μm. Infrared light, emitted from a broadly tunable quantum cascade laser with a wavelength resolution smaller than 20 nm, is coupled through the diamond waveguides for attenuated total reflection spectroscopy. The expected advantages of these waveguides are a high sensitivity due to the high number of internal reflections along the propagation direction, a high transmittance in the mid-IR domain, the bio-compatibility of diamond and the possibility of functionalizing the surface layer. The sensor will be used for analyzing different forms of proteins such as α-synuclein which is relevant in understanding the mechanism behind Parkinson's disease. The fabrication process of the waveguide, its characteristics and several geometries are introduced. The optical setup of the biosensor is described and our first measurements on two analytes to demonstrate the principle of the sensing method will be presented. Future use of this sensor includes the functionalization of the diamond waveguide sensor surface to be able to fish out alpha-synuclein from cerebrospinal fluid.

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P. Piron, E. Vargas Catalan, J. Haas, L. Österlund, F. Nikolajeff, P. O. Andersson, J. Bergström, B. Mizaikoff, and M. Karlsson "Development of a diamond waveguide sensor for sensitive protein analysis using IR quantum cascade lasers", Proc. SPIE 10539, Photonic Instrumentation Engineering V, 105390F (22 February 2018); https://doi.org/10.1117/12.2289844

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