Possible Implications Of Vascular Damage For Tumor Cell Inactivation In Vivo: Comparison Of Different Photosensitizers

Barbara W. Henderson; Gwendolyn Farrell

doi:10.1117/12.977998

13 June 1989 Possible Implications Of Vascular Damage For Tumor Cell Inactivation In Vivo: Comparison Of Different Photosensitizers

Barbara W. Henderson, Gwendolyn Farrell

Author Affiliations +

Proceedings Volume 1065, Photodynamic Therapy: Mechanisms; (1989) https://doi.org/10.1117/12.977998
Event: OE/LASE '89, 1989, Los Angeles, CA, United States

Abstract

Various different photosensitizers were compared to Photofrin® II with respect to their potential for causing direct tumor cell inactivation and/or vascular damage. GaCl-phthalocyanine of mixed sulfonation, while being 10 x more efficient than Photofrin® II in tumor cell inactivation, caused equal vascular photosensitization. Monosulfonated AlC1-phthalocyanine, on the other hand, was sparing to the vasculature, while still exhibiting good tumor cell effects. Large differences in vascular photosensitization were also observed with tetra- and monosulfonated tetraphenylporphines.

Citation Download Citation

Barbara W. Henderson and Gwendolyn Farrell "Possible Implications Of Vascular Damage For Tumor Cell Inactivation In Vivo: Comparison Of Different Photosensitizers", Proc. SPIE 1065, Photodynamic Therapy: Mechanisms, (13 June 1989); https://doi.org/10.1117/12.977998

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available