Crystallization behavior of biochemicals: morphologies and kinetics of complex multinary organics

N. B. Singh; Jayram Singh; Sarita Rai; Narsingh Bahadur Singh

doi:10.1117/12.2305726

14 May 2018 Crystallization behavior of biochemicals: morphologies and kinetics of complex multinary organics

N. B. Singh, Jayram Singh, Sarita Rai, Narsingh Bahadur Singh

Proceedings Volume 10662, Smart Biomedical and Physiological Sensor Technology XV; 1066206 (2018) https://doi.org/10.1117/12.2305726
Event: SPIE Commercial + Scientific Sensing and Imaging, 2018, Orlando, FL, United States

Abstract

Drug delivery is a very complex phenomenon. Most of the drugs are soluble in the water and flow easily in the body. However, drugs consisted of complex organics crystallize in different morphologies such as needles, plates, dendrites and organized lamellars. We have observed that 3.methoxy 4-hydroxybenzaldehyde also known as “vanillin” forms needles and plate morphologies in very small difference of pH or organic impurities and can crystallize in different forms. We have performed extensive studies to understand the crystallization of binary and ternary complex organic materials systems to understand the crystallization and morphologies. We will present the results of non-water-soluble organics using melt methods and discuss the mechanism of formation of different morphologies. More specifically results of 3.methoxy 4-hydroxybenzaldehyde-m.dinitrobenzene and 8- hydroxyquinoline-succinonitrile, systems will be discussed.

Conference Presentation

Citation Download Citation

N. B. Singh, Jayram Singh, Sarita Rai, and Narsingh Bahadur Singh "Crystallization behavior of biochemicals: morphologies and kinetics of complex multinary organics", Proc. SPIE 10662, Smart Biomedical and Physiological Sensor Technology XV, 1066206 (14 May 2018); https://doi.org/10.1117/12.2305726

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