Structural features of blood lymphocytes according to data of atomic force microscopy in alloxan induced diabetic rats

Olga V. Stolbovskaya; Radik M. Khayrullin; Boris B. Kostishko; Rinat I. Bakhtiyarov

doi:10.1117/12.2315077

26 April 2018 Structural features of blood lymphocytes according to data of atomic force microscopy in alloxan induced diabetic rats

Olga V. Stolbovskaya, Radik M. Khayrullin, Boris B. Kostishko, Rinat I. Bakhtiyarov

Author Affiliations +

Proceedings Volume 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX; 107160F (2018) https://doi.org/10.1117/12.2315077
Event: Saratov Fall Meeting 2017, 2017, Saratov, Russian Federation

Abstract

Structural changes in blood lymphocytes during the development of alloxan induced diabetes in rats were revealed. The changes were characterized by decreased volume, surface area, flatness coefficient of cells in comparison with normal lymphocytes. A consistent increase in the Young's modulus of rat lymphocytes during the development of diabetes in comparison with the Young's modulus of normal lymphocytes has been established, which indicates a decrease of the elastic-viscous properties of the cell membrane, changes in the molecular structure of its and in the organization of the lymphocyte cytoskeleton. It was found that during the development of induced diabetes the roughness and adhesiveness of the cytoplasmic membrane of blood lymphocytes decrease.

Citation Download Citation

Olga V. Stolbovskaya, Radik M. Khayrullin, Boris B. Kostishko, and Rinat I. Bakhtiyarov "Structural features of blood lymphocytes according to data of atomic force microscopy in alloxan induced diabetic rats", Proc. SPIE 10716, Saratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX, 107160F (26 April 2018); https://doi.org/10.1117/12.2315077

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available