Antioxidant, anti-inflammatory, and immunostimulatory activity of polysaccharide from artemisiae argyi folium

Jian-ping Deng; Tong-sheng Chen; Yi-fei Wang; Zhi-ping Wang

doi:10.1117/12.2500028

23 October 2018 Antioxidant, anti-inflammatory, and immunostimulatory activity of polysaccharide from artemisiae argyi folium

Jian-ping Deng, Tong-sheng Chen, Yi-fei Wang, Zhi-ping Wang

Author Affiliations +

Proceedings Volume 10820, Optics in Health Care and Biomedical Optics VIII; 1082017 (2018) https://doi.org/10.1117/12.2500028
Event: SPIE/COS Photonics Asia, 2018, Beijing, China

Abstract

As the traditional Chinese medicine, artemisiae argyi folium has various functions such as analgesia, antitumor, and anti-hypertension. To study antioxidant activity in vitro and cell-based anti-inflammatory activity of artemisiae argyi folium polysaccharide (AAFP). The antioxidant activity of AAFP was investigated by ABTS⁺ • clearance rate, DPPH•clearance rate, • OH clearance rate and FRAP assays. The lipopolysaccharide-induced RAW264.7 cell inflammation model was established to assess its anti-inflammatory activity. The results showed that the AAFP had strong antioxidant activity and the IC₅₀ on ABTS radicals, DPPH radicals, hydroxyl radicals, and the ferric reducing antioxidant power were 74.41, 268.5, 350.2μg/ml and the FRAP value was 163.5μg/ml. MTT experiments showed IC50 of AAFP was 441.5μg/ml. The quantitative polymerase chain reaction demonstrate the pro-inflammatory activity of AAFP. Immunological assay showed that AAFP significantly promoted lymphocyte proliferation. AAFP have huge potential to be developed as functional foods and medicines.

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Jian-ping Deng, Tong-sheng Chen, Yi-fei Wang, and Zhi-ping Wang "Antioxidant, anti-inflammatory, and immunostimulatory activity of polysaccharide from artemisiae argyi folium", Proc. SPIE 10820, Optics in Health Care and Biomedical Optics VIII, 1082017 (23 October 2018); https://doi.org/10.1117/12.2500028

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