Diagnostic possibilities of dynamic light scattering technique

Elina Nepomnyashchaya; Elena Velichko; Tatyana Bogomaz

doi:10.1117/12.2509847

5 March 2019 Diagnostic possibilities of dynamic light scattering technique

Elina Nepomnyashchaya, Elena Velichko, Tatyana Bogomaz

Proceedings Volume 10891, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI; 108910J (2019) https://doi.org/10.1117/12.2509847
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

The latest tendencies in individual diagnostics show high interest in development of optical methods. We have used a dynamic light scattering technique to study the size composition of proteins in blood serum of donors with different diseases. In this work, we focused our attention on demonstration of differences between size compositions of blood serum of donors with different types of diseases. It had been found that the proteins' size composition for sick donors differs in a certain way from the size map of healthy donors. Specifically, the relative concentrations of albumins, globulins and circulating immune complex can be used as a diagnostic parameter as it changes significantly on the disease. This result shows the possibilities of application of dynamic light scattering technique to analyze progress and stage of different diseases, in particular, immune diseases and oncology. We declare that the proposed dynamic light scattering technique can be used in medical practice for early fast and simple diagnostics.

Conference Presentation

Citation Download Citation

Elina Nepomnyashchaya, Elena Velichko, and Tatyana Bogomaz "Diagnostic possibilities of dynamic light scattering technique", Proc. SPIE 10891, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI, 108910J (5 March 2019); https://doi.org/10.1117/12.2509847

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