Comparisons of 6 fps volume-rendered x-ray digital tomosynthesis TumoTrak-guided to 2D-MRI-guided radiotherapy of lung cancer

Larry Partain; Stanley Benedict; Namho Kim; Megan Daly; Austin Ely; Andrew Hernandez; Samuel Song; Micheal Weil; Vitaliy Ziskin; Kyle Foletta; John Boone; Douglas Boyd

doi:10.1117/12.2511993

1 March 2019 Comparisons of 6 fps volume-rendered x-ray digital tomosynthesis TumoTrak-guided to 2D-MRI-guided radiotherapy of lung cancer

Larry Partain, Stanley Benedict, Namho Kim, Megan Daly, Austin Ely, Andrew Hernandez, Samuel Song, Micheal Weil, Vitaliy Ziskin, Kyle Foletta, John Boone, Douglas Boyd

Author Affiliations +

Proceedings Volume 10948, Medical Imaging 2019: Physics of Medical Imaging; 109483L (2019) https://doi.org/10.1117/12.2511993
Event: SPIE Medical Imaging, 2019, San Diego, California, United States

Abstract

Retrospective kV x-ray 4DCT treatment planning for lung cancer MV linac treatment is becoming a standard-of-care for this widely used procedure for the largest cancer cause-of-death in the US. It currently provides the best estimate of a fixed-in-time but undulating and closed 3D "shell" to which a minimum curative-intent radiation dose should be delivered to provide the best estimated patient survival and the least morbidity, usually characterized by quantitative dose-volume-histograms (DVHs). Unfortunately this closed shell volume or internal target volume (ITV) currently has to be increased enough to enclose the full range of respiratory lesion motion (plus set-up etc. uncertainties) which cannot yet be accurately determined in real time during treatment delivery. With accurate motion-tracking, the planning target volume (PTV) or outer “shell” may be reduced by up to 40%. However there is no single 2D plane that precisely follows the reduced-PTV-volume’s 3D respiratory motion, currently best estimated by the retrospective hand contouring by a trained and experienced MD radiation oncology MD using the full 3D-time information of 4DCT. Once available, 3D motion tracking in real time has the potential to substantially decrease DVH doses to surrounding organs-at-risk (OARs), while maintaining or raising the curative-intent dose to the lesion itself. The assertion argued here is that, the 3D volume-rendered imaging of lung cancer lesion-trajectories in real-time from TumoTrak digital x-ray tomosythesis, has the potential to provide more accurate 3D motion tracking and improved dose delivery at lower cost than the real time, 2D single slice imaging of MRI-guided radiotherapy.

Citation Download Citation

Larry Partain, Stanley Benedict, Namho Kim, Megan Daly, Austin Ely, Andrew Hernandez, Samuel Song, Micheal Weil, Vitaliy Ziskin, Kyle Foletta, John Boone, and Douglas Boyd "Comparisons of 6 fps volume-rendered x-ray digital tomosynthesis TumoTrak-guided to 2D-MRI-guided radiotherapy of lung cancer", Proc. SPIE 10948, Medical Imaging 2019: Physics of Medical Imaging, 109483L (1 March 2019); https://doi.org/10.1117/12.2511993

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
15 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Lung cancer

Radiotherapy

X-rays

Prototyping

Video

Digital imaging

Imaging systems

Show All Keywords

Keywords/Phrases

Search In:

Publication Years