Methylene blue as a photosensitizer in the photodynamic therapy of breast cancer cell lines

JC Atenco-Cuautle; T. Spezzia-Mazzocco; R. Ramos-Garcia; JC Ramirez-San-Juan; J. Ramirez-Ramirez; MG Delgado-Lopez

doi:10.1117/12.2525454

7 August 2019 Methylene blue as a photosensitizer in the photodynamic therapy of breast cancer cell lines

JC Atenco-Cuautle, T. Spezzia-Mazzocco, R. Ramos-Garcia, JC Ramirez-San-Juan, J. Ramirez-Ramirez, MG Delgado-Lopez

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 11070A0 (2019) https://doi.org/10.1117/12.2525454
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

We compared MB-PDT effect on two breast cancer cell lines: MDA-MB-231 from a triple negative adenocarcinoma, and T47D from a ductal cell tumor of woman. Methylene blue concentrations at 5, 10 and 20 μM and red light doses of 20, 40 and 60 J/cm² were employed. Cell viability was evaluated with the MTT test, obtaining around 80% of inhibition with 20 μM and 60 J/cm² of light dose.

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JC Atenco-Cuautle, T. Spezzia-Mazzocco, R. Ramos-Garcia, JC Ramirez-San-Juan, J. Ramirez-Ramirez, and MG Delgado-Lopez "Methylene blue as a photosensitizer in the photodynamic therapy of breast cancer cell lines", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 11070A0 (7 August 2019); https://doi.org/10.1117/12.2525454

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