Hollow gold nanoshells modified with PEG: synthesis and application as photothermal agents

I. Grabowska-Jadach; M. Drozd; D. Kalinowska; M. Pietrzak; Z. Iwoń; E. Malinowska; Z. Brzózka; A. Dybko

doi:10.1117/12.2526928

22 July 2019 Hollow gold nanoshells modified with PEG: synthesis and application as photothermal agents

I. Grabowska-Jadach, M. Drozd, D. Kalinowska, M. Pietrzak, Z. Iwoń, E. Malinowska, Z. Brzózka, A. Dybko

Proceedings Volume 11075, Novel Biophotonics Techniques and Applications V; 110751H (2019) https://doi.org/10.1117/12.2526928
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

The main purpose of the presented studies were both cytotoxicity studies of the developed hollow gold nanoshells and examination of their applications as photothermal agents. We decided to used hollow gold nanoshells as photoactive agents in photothermal therapy (PTT) due to their suitable optical properties, which are essential for this kind of tumor therapy. Nanoparticles were obtained by the galvanic replacement method. We confirmed excellent optical and photothermal properties of surface modified (with PEG-COOH and PEG-NH₂) nanoparticles. Then cytotoxicity studies were conducted on two selected human cell lines: A375 (malignant melanoma) and HaCaT (aneuploid keratinocyte). Cells viability was evaluated using MTT test. Finally, we evaluated effectiveness of PTT based on AuNPs-PEG-COOH or AuNPs-PEG-NH₂.

Citation Download Citation

I. Grabowska-Jadach, M. Drozd, D. Kalinowska, M. Pietrzak, Z. Iwoń, E. Malinowska, Z. Brzózka, and A. Dybko "Hollow gold nanoshells modified with PEG: synthesis and application as photothermal agents", Proc. SPIE 11075, Novel Biophotonics Techniques and Applications V, 110751H (22 July 2019); https://doi.org/10.1117/12.2526928

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available