Focused x-ray luminescence computed tomography

Michael C. Lun; Changqing Li

doi:10.1117/12.2532096

10 September 2019 Focused x-ray luminescence computed tomography

Michael C. Lun, Changqing Li

Proceedings Volume 11113, Developments in X-Ray Tomography XII; 111131B (2019) https://doi.org/10.1117/12.2532096
Event: SPIE Optical Engineering + Applications, 2019, San Diego, California, United States

Abstract

X-ray luminescence computed tomography (XLCT) is an emerging hybrid molecular imaging modality and has shown great promises in overcoming the strong optical scattering in deep tissues. Though the narrow x-ray beam based XLCT imaging has been demonstrated to obtain high spatial resolution at depth, it suffers from a relatively long measurement time, hindering its practical applications. Recently, we have designed a focused x-ray beam based XLCT imaging system and have successfully performed imaging in about 7.5 seconds per section for a mouse sized object. However, its high spatial resolution capacity has not been fully implemented yet. In this paper, with a superfine focused x-ray beam we design a focused-x-ray luminescence tomography (FXLT) system for spatial resolution up to 94 μm. First, we have described our design in details. Then, we estimate the performance of the designed FXLT imaging system. Lastly, we have found that the spatial resolution of FXLT can be further improved by reducing the scan step size, which has been demonstrated by numerical simulations.

Citation Download Citation

Michael C. Lun and Changqing Li "Focused x-ray luminescence computed tomography", Proc. SPIE 11113, Developments in X-Ray Tomography XII, 111131B (10 September 2019); https://doi.org/10.1117/12.2532096

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KEYWORDS

X-rays

Imaging systems

Spatial resolution

X-ray imaging

Numerical simulations

X-ray detectors

Luminescence

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