Neurovascular coupling, the close spatial and temporal relationship between neural activity and hemodynamics, is disrupted in pathological brain states. To understand the altered neurovascular relationship in abnormal brain states, longitudinal, simultaneous mapping of neural activity and hemodynamics is highly desired but challenging to achieve. Here, we report the development of a multimodal neural platform that realize long-term, spatially-resolved tracking of intracortical neural activity and cerebral blood flow in the same brain regions. We demonstrate the powerful application of this multimodal platform in a mouse model of microinfarcts and reveal a pronounced, long-lasting neurovascular dissociation that depends on the ischemic severity.
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