Intraoperative margin assessment of breast-conserving surgery resections using x-ray micro-computed tomography and optical structured light (Conference Presentation)

Samuel S. Streeter; Benjamin W. Maloney; Elizabeth J. Rizzo; Michael Jermyn; Wendy A. Wells; Richard J. Barth Jr.; Keith D. Paulsen; Brian W. Pogue

doi:10.1117/12.2542827

9 March 2020 Intraoperative margin assessment of breast-conserving surgery resections using x-ray micro-computed tomography and optical structured light (Conference Presentation)

Samuel S. Streeter, Benjamin W. Maloney, Elizabeth J. Rizzo, Michael Jermyn, Wendy A. Wells, Richard J. Barth Jr., Keith D. Paulsen, Brian W. Pogue

Author Affiliations +

Proceedings Volume 11232, Multimodal Biomedical Imaging XV; 112320C (2020) https://doi.org/10.1117/12.2542827
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

The most common treatment for early-stage breast cancer involves breast-conserving surgery (BCS), which is a local resection of malignant tissue. BCS success relies on the presence of healthy tissue margins surrounding each resection. However, approximately 20% of BCS patients require follow-up surgery to remove residual tumor. Micro-computed tomography and optical structured light imaging were investigated for intraoperative margin assessment. Specimens were imaged immediately after resection and before surgical inking, and image data were compared to postoperative histopathology. The study demonstrated the feasibility of imaging during BCS and generated a baseline multimodal dataset of whole BCS resections, including positive margin signatures.

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Samuel S. Streeter, Benjamin W. Maloney, Elizabeth J. Rizzo, Michael Jermyn, Wendy A. Wells, Richard J. Barth Jr., Keith D. Paulsen, and Brian W. Pogue "Intraoperative margin assessment of breast-conserving surgery resections using x-ray micro-computed tomography and optical structured light (Conference Presentation)", Proc. SPIE 11232, Multimodal Biomedical Imaging XV, 112320C (9 March 2020); https://doi.org/10.1117/12.2542827

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KEYWORDS

Surgery

Laser imaging

Optical tomography

Structured light

Tissues

Tomography

X-rays

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