Photosensitizing effect of Photolon using optical fiber probe to laser-irradiate thyroid cancer cells: oxidative stress-directed cell death

GaYe Park; Yun-Hee Rhee; HyeYeon Lee; Junho Lee; Hyunjoo Kim; ChangHyun Jung; Jaesun Kim; ChiHwan Ouh; Phil-Sang Chung

doi:10.1117/12.2545787

20 February 2020 Photosensitizing effect of Photolon using optical fiber probe to laser-irradiate thyroid cancer cells: oxidative stress-directed cell death

GaYe Park, Yun-Hee Rhee, HyeYeon Lee, Junho Lee, Hyunjoo Kim, ChangHyun Jung, Jaesun Kim, ChiHwan Ouh, Phil-Sang Chung

Author Affiliations +

Proceedings Volume 11233, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XX; 112330L (2020) https://doi.org/10.1117/12.2545787
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

In this study, Cylindrical Diffusing Optical Fiber Probe (CDOFP) is used for tumor treatment using Photolon-based photodynamic therapy induced apoptosis and necrosis in thyroid papillary carcinoma (BCPAP) cells. In conclusion, owing to multiple advantageous properties of Photolon as a PDT agent, including preferential accumulation in tumor, biodegradability and unprecedented photosensitizer packing, we evaluate Photolon mediated PDT as a minimally invasive, tumor specific treatment for thyroid cancer. the Photolon-PDT inhibited the growth of human papilloma thyroid cancer cells and effectively decreased xenograft tumor progression in both 10mm and 15mm diffusing length probe. Therefore, this study preliminarily suggests the use of CDOFP and Photolon-PDT for more effective treatment of human thyroid cancer.

Citation Download Citation

GaYe Park, Yun-Hee Rhee, HyeYeon Lee, Junho Lee, Hyunjoo Kim, ChangHyun Jung, Jaesun Kim, ChiHwan Ouh, and Phil-Sang Chung "Photosensitizing effect of Photolon using optical fiber probe to laser-irradiate thyroid cancer cells: oxidative stress-directed cell death", Proc. SPIE 11233, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XX, 112330L (20 February 2020); https://doi.org/10.1117/12.2545787

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