The presence and location of podocytes in glomeruli as affected by diabetes mellitus

Kathryn E. Maraszek; Briana A. Santo; Rabi Yacoub; John E. Tomaszewski; Imtiaz Mohammad; Amber M. Worral; Pinaki Sarder

doi:10.1117/12.2548904

16 March 2020 The presence and location of podocytes in glomeruli as affected by diabetes mellitus

Kathryn E. Maraszek, Briana A. Santo, Rabi Yacoub, John E. Tomaszewski, Imtiaz Mohammad, Amber M. Worral, Pinaki Sarder

Proceedings Volume 11320, Medical Imaging 2020: Digital Pathology; 1132018 (2020) https://doi.org/10.1117/12.2548904
Event: SPIE Medical Imaging, 2020, Houston, Texas, United States

Abstract

The primary purpose of the kidney, specifically the glomerulus, is filtration. Filtration is accomplished through the glomerular filtration barrier, which consists of the fenestrated endothelium, glomerular basement membrane, and specialized epithelial cells called podocytes. In pathologic states, such as Diabetes Mellitus (DM) and diabetic kidney disease (DKD), variable glomerular conditions result in podocyte injury and depletion, followed by progressive glomerular injury and DKD progression. In this work we quantified glomerulus and podocyte structural changes in histopathology image data derived from a murine model of DM. Using a variety of image processing techniques, we studied changes in podocyte morphology and intra-glomerular distribution across healthy, mild DM, and DM glomeruli. Our feature analysis provided feature trends which we believe are reflective of DKD pathology; while glomerular area peaked in mild DM, average podocyte number and distance from the urinary pole continued to increase throughout DM. Ultimately, this study aims to augment the set of quantifiable image biomarkers used for evaluation of DKD progression in digital pathology, as well as underscore the importance of engineering biologically inspired image features.

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Kathryn E. Maraszek, Briana A. Santo, Rabi Yacoub, John E. Tomaszewski, Imtiaz Mohammad, Amber M. Worral, and Pinaki Sarder "The presence and location of podocytes in glomeruli as affected by diabetes mellitus", Proc. SPIE 11320, Medical Imaging 2020: Digital Pathology, 1132018 (16 March 2020); https://doi.org/10.1117/12.2548904

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KEYWORDS

Image segmentation

Kidney

Pathology

Injuries

Binary data

Tissues

Image processing

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