Skin autofluorescence measured with fluorescent spectrometry and blood lipids level in diabetic patients

Yulia A. Kononova; Daria A. Fedostsova; Ekaterina A. Dvoretskaya; Garry V. Papayan; Alina Yu. Babenko; Elena N. Grineva

doi:10.1117/12.2555940

17 April 2020 Skin autofluorescence measured with fluorescent spectrometry and blood lipids level in diabetic patients

Yulia A. Kononova, Daria A. Fedostsova, Ekaterina A. Dvoretskaya, Garry V. Papayan, Alina Yu. Babenko, Elena N. Grineva

Proceedings Volume 11362, Clinical Biophotonics; 113620E (2020) https://doi.org/10.1117/12.2555940
Event: SPIE Photonics Europe, 2020, Online Only

Abstract

Background. The aim of our study was to estimate the association of lipid fractions and skin autofluorescence (AF), measured with experimental sample of fiber optic spectrometer FOS-1, in patients with diabetes mellitus (DM). Methods. We included in the study 44 type 1 DM patients (median age 29.5 (24.0; 36.0) and 23 type 2 DM patients, median age 58.0 (47.0; 61.0). Blood lipids and glycosylated hemoglobin (HbA1c) were analyzed. Skin AF was measured with fluorescence–reflection spectrometer FOS-1 at a wavelength of 460 nm with excitation of 365 nm. Ratio of fluorescent signal to signal of reflection in excitation region was used as measured parameter to reduce the effect of skin pigmentation. The measurements were carried out at 5 points on the skin area of forearms. Results. Type 1 DM group was divided to 13 dyslipidemic and 31 normolipidemic patients, subgroups were comparable by age, DM duration and HbA1c level. AF level in dyslipidemic and normolipidemic patients was 0.95 (0.82; 1.16) arb. units and 0.86 (0.79; 0.91) arb. units respectively, p=0.016. In type 1 DM group we found significant positive correlation between skin AF and total cholesterol level (R=0.45, р<0.05) and triglycerides level (R=0.57, p<0.05). In type 2 DM group no lipid fraction showed significant positive correlation with skin AF level. Conclusion. The spectrometer FOS-1 can be used for additional risk evaluation in young and middle-aged type 1 DM patients, but simultaneous presence of several risk factors in older group of type 2 DM patients obstruct the use of the method.

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Yulia A. Kononova, Daria A. Fedostsova, Ekaterina A. Dvoretskaya, Garry V. Papayan, Alina Yu. Babenko, and Elena N. Grineva "Skin autofluorescence measured with fluorescent spectrometry and blood lipids level in diabetic patients", Proc. SPIE 11362, Clinical Biophotonics, 113620E (17 April 2020); https://doi.org/10.1117/12.2555940

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