Using in utero optical coherence tomography to evaluate changes in murine fetal brain vasculature due to prenatal exposure to teratogens (Conference Presentation)

Raksha Raghunathan; Chih-Hao Liu; Amur Kouka; Yogeshwari Sanjayrao Ambekar; Connie Yan; Noemi Bustamante; Manmohan Singh; Rajesh C. Miranda; Kirill V. Larin

doi:10.1117/12.2555621

2 April 2020 Using in utero optical coherence tomography to evaluate changes in murine fetal brain vasculature due to prenatal exposure to teratogens (Conference Presentation)

Raksha Raghunathan, Chih-Hao Liu, Amur Kouka, Yogeshwari Sanjayrao Ambekar, Connie Yan, Noemi Bustamante, Manmohan Singh, Rajesh C. Miranda, Kirill V. Larin

Author Affiliations +

Proceedings Volume 11363, Tissue Optics and Photonics; 1136303 (2020) https://doi.org/10.1117/12.2555621
Event: SPIE Photonics Europe, 2020, Online Only

Abstract

One of the most common reasons of congenital birth defects is prenatal substance abuse. The severity of the defect depends on the amount of substance abused and the period of gestation during which substance is abused. Although prenatal substance abuse is common during the first trimester, some women continue the abuse well into their second trimester, which is considered the peak period for fetal neurogenesis and angiogenesis. Thus, evaluating the changes in fetal brain vasculature caused by maternal exposure to different teratogens at the second trimester equivalent period is crucial. In this study we use correlation mapping optical coherence angiography (cm-OCA), a functional extension of optical coherence tomography, to image changes in murine fetal brain vasculature caused due to prenatal exposure to ethanol, cannabinoids, or nicotine. Results showed significant vasoconstriction in all three cases.

Conference Presentation

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Raksha Raghunathan, Chih-Hao Liu, Amur Kouka, Yogeshwari Sanjayrao Ambekar, Connie Yan, Noemi Bustamante, Manmohan Singh, Rajesh C. Miranda, and Kirill V. Larin "Using in utero optical coherence tomography to evaluate changes in murine fetal brain vasculature due to prenatal exposure to teratogens (Conference Presentation)", Proc. SPIE 11363, Tissue Optics and Photonics, 1136303 (2 April 2020); https://doi.org/10.1117/12.2555621

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