Laser Doppler flowmetry in assessing the distant stimulating effect by autotransplantation of skin flap on microcirculation

Era B. Popyhova; Tatiana V. Stepanova; Ekaterina V. Gladkova; Irina V. Babushkina; Daria D. Lagutina; Aleksei N. Ivanov

doi:10.1117/12.2559840

9 April 2020 Laser Doppler flowmetry in assessing the distant stimulating effect by autotransplantation of skin flap on microcirculation

Era B. Popyhova, Tatiana V. Stepanova, Ekaterina V. Gladkova, Irina V. Babushkina, Daria D. Lagutina, Aleksei N. Ivanov

Author Affiliations +

Proceedings Volume 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine; 114570C (2020) https://doi.org/10.1117/12.2559840
Event: Saratov Fall Meeting 2019: VII International Symposium on Optics and Biophotonics, 2019, Saratov, Russian Federation

Abstract

Chronic hyperglycemia in diabetes mellitus (DM) is the pathogenetic basis for the occurrence and development of macro- and microvascular disorders, which provoke the development of retinopathy, nephropathy and cause the accelerated development of atherosclerosis with damage to the coronary, cerebral and peripheral vessels. This determines the relevance of developing new methods for the correction of disorders of carbohydrate metabolism, including nonpharmacological ones. Using the method of laser Doppler flowmetry, microcirculation disorders in rats caused by alloxan insulin deficiency were studied. Disruption of microcirculation was manifested by a decrease in perfusion index on the skin of the dorsum of the foot in combination with a decrease in the normalized amplitudes of endothelial and neurogenic oscillations. An animals that have non-pharmacological correction (autotransplantation of the skin flap) of carbohydrate metabolism disorders, an increase in perfusion index relative to the comparison group was observed on day 42 of the experiment, indicating an improvement in microcirculation. An increase in the normalized amplitudes of endothelial and neurogenic oscillations relative to the comparison group was also noted. The data obtained allow us to conclude that the use of laser Doppler fluometry in the study of the functional state of the microvasculature and the diagnosis of vascular complications of diabetes is very promising.

Citation Download Citation

Era B. Popyhova, Tatiana V. Stepanova, Ekaterina V. Gladkova, Irina V. Babushkina, Daria D. Lagutina, and Aleksei N. Ivanov "Laser Doppler flowmetry in assessing the distant stimulating effect by autotransplantation of skin flap on microcirculation", Proc. SPIE 11457, Saratov Fall Meeting 2019: Optical and Nano-Technologies for Biology and Medicine, 114570C (9 April 2020); https://doi.org/10.1117/12.2559840

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
5 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Skin

Doppler effect

Mode conditioning cables

Blood

Animal model studies

Tissues

Blood circulation

Show All Keywords

Keywords/Phrases

Search In:

Publication Years