5 March 2021Quantifying the confounding effect of pigmentation on measured skin tissue optical properties: A comparison of colorimetry with Spatial Frequency Domain Imaging
Thinh Phan,1 Rebecca Rowlandhttps://orcid.org/0000-0002-8913-9599,1 Adrien Ponticorvo,1 Binh C Le,1 Robert H. Wilson,1 Seyed A. Sharif,1 Gordon T. Kennedy,1 Anthony J. Durkin2
1Beckman Laser Institute and Medical Clinic (United States) 2Univ. of California, Irvine (United States)
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Spatial frequency domain imaging (SFDI) is a wide-field spectral imaging technique that can be used to characterize optical properties of in-vivo tissue. Typically, SFDI uses light transport modeling based on Monte Carlo simulations to analyze the detected diffuse reflectance. Here, we examined the effect of using a semi-infinite homogeneous tissue model to determine optical properties of in-vivo human skin across a full range of pigmentation levels. We analyzed µs’ curves and performed correlation analysis between µs’ and degree of pigmentation determined using a tristimulus colorimeter. Our results suggested that pigmentation’s effect on µs’ is minimal at near-infrared wavelengths.
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Thinh Phan, Rebecca Rowland, Adrien Ponticorvo, Binh C Le, Robert H. Wilson, Seyed A. Sharif, Gordon T. Kennedy, Anthony J. Durkin, "Quantifying the confounding effect of pigmentation on measured skin tissue optical properties: A comparison of colorimetry with Spatial Frequency Domain Imaging," Proc. SPIE 11618, Photonics in Dermatology and Plastic Surgery 2021, 1161810 (5 March 2021); https://doi.org/10.1117/12.2576800