Monitoring bone healing in animal model and human using diffuse optics

Regine Choe

doi:10.1117/12.2590875

5 March 2021 Monitoring bone healing in animal model and human using diffuse optics

Regine Choe

Proceedings Volume 11622, Multiscale Imaging and Spectroscopy II; 1162208 (2021) https://doi.org/10.1117/12.2590875
Event: SPIE BiOS, 2021, Online Only

Abstract

Even though vascularization is recognized as an important factor in bone healing, there are limitations in terms of assessing vascularization in both preclinical and clinical scenarios. Diffuse optics have a potential to fill this gap by providing deep-tissue, non-invasive, longitudinal monitoring of total hemoglobin concentration, blood oxygen saturation and blood flow. Using rodent models with bone grafts or bone fractures, we will demonstrate the potential to build a prediction model for bone treatment efficacy assessment. In addition, the construction of a multi-modal diffuse optical imager to detect nonunion and monitor treatment in foot fractures will be introduced. Validation studies to compare diffuse optics with gold standard methods will be presented.

Conference Presentation

Citation Download Citation

Regine Choe "Monitoring bone healing in animal model and human using diffuse optics", Proc. SPIE 11622, Multiscale Imaging and Spectroscopy II, 1162208 (5 March 2021); https://doi.org/10.1117/12.2590875

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