Modulatory effect of NCX on IP3-dependent Ca2+ oscillations in astrocytes

Andrey Yu. Verisokin; Darya V. Verveyko; Varvara V. Kucherenko; Dmitry E. Postnov; Alexey R. Brazhe

doi:10.1117/12.2590417

4 May 2021 Modulatory effect of NCX on IP₃-dependent Ca²⁺ oscillations in astrocytes

Andrey Yu. Verisokin, Darya V. Verveyko, Varvara V. Kucherenko, Dmitry E. Postnov, Alexey R. Brazhe

Proceedings Volume 11847, Saratov Fall Meeting 2020: Computations and Data Analysis: from Molecular Processes to Brain Functions; 1184705 (2021) https://doi.org/10.1117/12.2590417
Event: Saratov Fall Meeting 2020, 2020, Saratov, Russian Federation

Abstract

Most of the existing models of calcium dynamics of astrocytes do not take into account the effect of the Na/Ca- exchanger on the formation of calcium oscillations and their properties. However, recent experimental studies show that at an increased sodium concentration, the Na/Ca-exchanger works in the reverse mode, providing an additional calcium entry into the cell cytosol. In this work we study a model that simultaneously takes into account the IP₃-mediated exchange with intracellular [Ca²⁺] stores and bidirectional [Ca²⁺] flow through Na/Ca-exchanger. We analyze the behavior of the system under stimulation with external glutamate- of the cell, explore the possible behavior regimes and reveal the effect of the cytosolic sodium concentration, the maximum current through the Na/Ca-exchanger, and the stimulus amplitude on the astrocytic calcium dynamics.

Citation Download Citation

Andrey Yu. Verisokin, Darya V. Verveyko, Varvara V. Kucherenko, Dmitry E. Postnov, and Alexey R. Brazhe "Modulatory effect of NCX on IP₃-dependent Ca²⁺ oscillations in astrocytes", Proc. SPIE 11847, Saratov Fall Meeting 2020: Computations and Data Analysis: from Molecular Processes to Brain Functions, 1184705 (4 May 2021); https://doi.org/10.1117/12.2590417

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