Light-activated drug release using an automated well plate illuminator

Laura Vesala; Robert Perttilä; Elias Kokko; Lasse Orsila; Petteri Uusimaa

doi:10.1117/12.2608745

4 March 2022 Light-activated drug release using an automated well plate illuminator

Laura Vesala, Robert Perttilä, Elias Kokko, Lasse Orsila, Petteri Uusimaa

Proceedings Volume 11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX; 1194003 (2022) https://doi.org/10.1117/12.2608745
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Efficient site-specific delivery of systemic therapeutic drugs is crucial especially in oncology but has proved to be challenging. Drugs can be encapsulated into liposomes that offer improved therapeutic index and distribution of the drug. The release of the drug can be efficiently achieved by integrating light-sensitive component into liposomes and applying near-infrared light in a time- and site-specific manner. Modulight has designed a cloud-connected ML8500 automated biomedical illumination system to specifically study in vitro drug release. The design is flexible, allowing up to eight Modulight semiconductor lasers of different wavelengths to be installed in one system, as well as the capability to be configured for different well plates, depending on the application requirements. The system includes an enhanced environmental control unit to ensure that the samples are investigated in physiologically relevant conditions. This enables also mimicking pathological conditions since drug release by light can have very different efficacy in these special conditions. Here we present an important case study regarding the utilization of the ML8500 system to investigate light-activated indocyanine green based liposomes which have been previously demonstrated to have great potential as advanced drug delivery systems.

Conference Presentation

Citation Download Citation

Laura Vesala, Robert Perttilä, Elias Kokko, Lasse Orsila, and Petteri Uusimaa "Light-activated drug release using an automated well plate illuminator", Proc. SPIE 11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX, 1194003 (4 March 2022); https://doi.org/10.1117/12.2608745

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