Phase decorrelation-OCT for monitoring the depth-dependent effect of accelerated corneal crosslinking

Brecken J. Blackburn; Matthew McPheeters; Michael Jenkins; William J. Dupps Jr.; Andrew Rollins

doi:10.1117/12.2609215

7 March 2022 Phase decorrelation-OCT for monitoring the depth-dependent effect of accelerated corneal crosslinking

Brecken J. Blackburn, Matthew McPheeters, Michael Jenkins, William J. Dupps Jr., Andrew Rollins

Proceedings Volume 11941, Ophthalmic Technologies XXXII; 1194108 (2022) https://doi.org/10.1117/12.2609215
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

While previously published work demonstrated the overall sensitivity of phase decorrelation optical coherence tomography (PhD-OCT) to crosslinking (CXL) in the cornea, it did not capitalize on the depth-resolving capability of PhD-OCT. Here, PhD-OCT was used to observe the depth-dependent differences in accelerated crosslinking efficiency with and without supplemental oxygen. Traditional crosslinking showed good crosslink formation in the anterior stroma. For accelerated CXL with supplemental oxygen, a significant stiffening effect was seen throughout the stroma. No stiffening was observed in accelerated CXL without supplemental oxygen or sham treatment. Thus, PhD-OCT may observe depth-dependent, protocol-specific changes in corneal tissue due to crosslinking.

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Citation Download Citation

Brecken J. Blackburn, Matthew McPheeters, Michael Jenkins, William J. Dupps Jr., and Andrew Rollins "Phase decorrelation-OCT for monitoring the depth-dependent effect of accelerated corneal crosslinking", Proc. SPIE 11941, Ophthalmic Technologies XXXII, 1194108 (7 March 2022); https://doi.org/10.1117/12.2609215

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KEYWORDS

Oxygen

Cornea

Optical coherence tomography

Tissues

Ultraviolet radiation

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