Improved sensitivity to deep tissues using phase-based structured interrogation frequency-domain near-infrared spectroscopy

Ola Abdalsalam; Scott Howard; Thomas D. O'Sullivan

doi:10.1117/12.2609662

4 March 2022 Improved sensitivity to deep tissues using phase-based structured interrogation frequency-domain near-infrared spectroscopy

Ola Abdalsalam, Scott Howard, Thomas D. O'Sullivan

Author Affiliations +

Proceedings Volume 11944, Multiscale Imaging and Spectroscopy III; 119440A (2022) https://doi.org/10.1117/12.2609662
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We present a new frequency-domain near-infrared spectroscopy method for extracting deep tissue information in heterogeneous tissues by interfering multiple intensity-modulated light sources. This method of structured interrogation (SI) can alter the spatial distribution of depth sensitivity, and therefore target different depths in the tissue. We found through analytical theory and a simulation study that SI has enhanced sensitivity to dynamic changes in deeper tissues and reduced sensitivity to superficial layers compared to multi-distance (MD) measurements. We also demonstrate that SI phase-only measurements are sufficient to accurately estimate optical properties.

Conference Presentation

Citation Download Citation

Ola Abdalsalam, Scott Howard, and Thomas D. O'Sullivan "Improved sensitivity to deep tissues using phase-based structured interrogation frequency-domain near-infrared spectroscopy", Proc. SPIE 11944, Multiscale Imaging and Spectroscopy III, 119440A (4 March 2022); https://doi.org/10.1117/12.2609662

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