Applications of time-resolved light scattering measurements to photodynamic therapy dosimetry

Michael S. Patterson; John David Moulton; Brian C. Wilson; Britton Chance

doi:10.1117/12.17652

1 July 1990 Applications of time-resolved light scattering measurements to photodynamic therapy dosimetry

Michael S. Patterson, John David Moulton, Brian C. Wilson, Britton Chance

Proceedings Volume 1203, Photodynamic Therapy: Mechanisms II; (1990) https://doi.org/10.1117/12.17652
Event: OE/LASE '90, 1990, Los Angeles, CA, United States

Abstract

Since biological response to photodynamic therapy (PDT) depends on the light fluence distribution and photosensitizer concentration in the tissue, these two variables should ideally be measured noninvasively in individual cases. This can be reduced to determining the optical absorption and transport scattering coefficients of the tissue because, if these two parameters are known, the fluence distribution can be calculated and the photosensitizer concentration can be deduced from its characteristic contribution to the absorption spectrum. The temporal spreading of a picosecond laser pulse as it propagates through tissue carries infonnation about both the scattering and absorption properties of the tissue. A mathematical model is presented which allows derivation of the interaction coefficients from the pulse shape, and preliminary experiments are reported which demonstrate the potential of these techniques in PDT dosimetry. Equivalent information can be obtained in the frequency domain by using modulated light sources andmeasuring thephase and modulation of the detected light. Analytical expressions are developed for these observable quantities in terms ofthe optical interaction coefficients. Particular auention is drawn to the potential oflow (less than 200 MHz) frequency measurements as these can be made with relatively simple instrumentation.

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Michael S. Patterson, John David Moulton, Brian C. Wilson, and Britton Chance "Applications of time-resolved light scattering measurements to photodynamic therapy dosimetry", Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); https://doi.org/10.1117/12.17652

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