Photodetection of early cancer by laser-induced fluorescence of a tumor-selective dye: apparatus design and realization

Georges A. Wagnieres; Christian D. Depeursinge; Philippe Monnier; Jean-Francois Savary; Piet Francois Cornaz; Andre Chatelain; Hubert van den Bergh

doi:10.1117/12.17649

1 July 1990 Photodetection of early cancer by laser-induced fluorescence of a tumor-selective dye: apparatus design and realization

Georges A. Wagnieres, Christian D. Depeursinge, Philippe Monnier, Jean-Francois Savary, Piet Francois Cornaz, Andre Chatelain, Hubert van den Bergh

Author Affiliations +

Proceedings Volume 1203, Photodynamic Therapy: Mechanisms II; (1990) https://doi.org/10.1117/12.17649
Event: OE/LASE '90, 1990, Los Angeles, CA, United States

Abstract

An apparatus is designed and realized to detect "early" cancer at the surface of the hollow organs in the human body by endoscopic means. The tumor is localized by the laser induced fluorescence of a dye (HPD) which concentrates selectively in the neoplastic tissue after intravenous injection. Fluorescence contrast between the tumor and its normal surroundings is enhanced by subtracting the background autofluorescence which occurs in both types of tissue. This is done by means of 2-color digital images manipulation in real-time. Preliminary clinical tests of the apparatus demonstrated the detection of carcinoma in situ in the esophagus.

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Georges A. Wagnieres, Christian D. Depeursinge, Philippe Monnier, Jean-Francois Savary, Piet Francois Cornaz, Andre Chatelain, and Hubert van den Bergh "Photodetection of early cancer by laser-induced fluorescence of a tumor-selective dye: apparatus design and realization", Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); https://doi.org/10.1117/12.17649

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