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4 April 2022 Evaluation of a cardiac flow phantom for absolute myocardial perfusion SPECT measurements
M. E. Kamphuis, Marcel J. W. G. Greuter, R. H. J. A. Slart, Cornelis H. Slump
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Proceedings Volume 12036, Medical Imaging 2022: Biomedical Applications in Molecular, Structural, and Functional Imaging; 1203626 (2022) https://doi.org/10.1117/12.2623667
Event: SPIE Medical Imaging, 2022, San Diego, California, United States
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Abstract
Absolute myocardial perfusion imaging (MPI) can be beneficial in the diagnosis and prognosis of patients with coronary artery disease. However, validation and standardization of perfusion estimates across centers is needed to ensure safe and adequate integration into clinical routine. MPI phantoms can contribute to this clinical need as these models can provide ground truth evaluation of absolute MPI in a simplified, though controlled setup. This work presents verification of phantom design choices, including the justification for using sorbents in mimicking contrast kinetics (i.e., tracer uptake and retention). Moreover, we compare preliminary phantom results obtained with SPECT-MPI with a patient example. Finally, we applied a general two-tissue compartment model to describe the obtained phantom time activity curve data. These evaluation steps support shaping of a suitable verification and validation strategy for the multimodal myocardial perfusion phantom design and realization.
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M. E. Kamphuis, Marcel J. W. G. Greuter, R. H. J. A. Slart, and Cornelis H. Slump "Evaluation of a cardiac flow phantom for absolute myocardial perfusion SPECT measurements", Proc. SPIE 12036, Medical Imaging 2022: Biomedical Applications in Molecular, Structural, and Functional Imaging, 1203626 (4 April 2022); https://doi.org/10.1117/12.2623667
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KEYWORDS
Single photon emission computed tomography
Data modeling
Differential equations
Positron emission tomography
Standards development
Software validation
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