Multispectral imaging for intraoperative functional brain mapping: perspectives and new developments

Yijing Xie

doi:10.1117/12.2654640

11 January 2023 Multispectral imaging for intraoperative functional brain mapping: perspectives and new developments

Yijing Xie

Proceedings Volume 12338, Hyperspectral Imaging and Applications II; 123380C (2023) https://doi.org/10.1117/12.2654640
Event: SPIE Photonex, 2022, Birmingham, United Kingdom

Abstract

In the brain tumour resection surgery, functional brain mapping (FBM) has been adapted in the contemporary neurosurgical workflow for improved surgical outcome. It allows neurosurgeons to identify and preserve brain regions with critical functions, thus to prevent post-surgical neurological deficits. However, there is no effective ways to directly visualize brain functions in real-time intraoperatively. A compact functional brain imaging device that can be more easily utilised during surgery is highly desired. We’ve been developing a multispectral imaging system (MSI) with the aim to fill this unmet clinical need. The device has been designed to detect brain functional activity by characterising light reflectance changes due to the blood oxygenation/flow fluctuation and neuronal membrane change. Co-localised MSI and fMRI measurements have been performed for detecting brain response to external electrical stimulations on preclinical animal models. Results suggested MSI could be able to identify the stimulation-evoked brain region as validated by the fMRI findings

Conference Presentation

Citation Download Citation

Yijing Xie " Multispectral imaging for intraoperative functional brain mapping: perspectives and new developments", Proc. SPIE 12338, Hyperspectral Imaging and Applications II, 123380C (11 January 2023); https://doi.org/10.1117/12.2654640

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