Corneal disease is the fifth leading cause of global blindless. Optical coherence tomography (OCT) for anterior imaging is extensively used due to its non-invasive and high-resolution volumetric imaging characteristics. Optical coherence microscopy (OCM) is a technical variation of OCT that can image the cornea with cellular resolution. Here, we demonstrate a visible-light OCM as a low-cost and easily reproducible system to visualize various corneal cellular structures such as epithelial cells, endothelial cells, keratocytes, and collagen bundles within stromal lamellae. The visible-light OCM was also used to study pressure changes in anterior segment human donor eyes. The system achieved an axial resolution of 12 μm in tissue over a 1.2 mm imaging depth, and a lateral resolution of 1.6 µm over a field of view of up to 750 μm × 750 μm.
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