Time-correlated Raman imaging with a SPAD line sensor

Neil Finlayson; Heather McEwan; Gillian E. Brown; Alistair Gorman; Andrey Gromov; Colin J. Campbell; Ahmet Erdogan; Robert K. Henderson; Gareth O. S. Williams

doi:10.1117/12.2648899

6 March 2023 Time-correlated Raman imaging with a SPAD line sensor

Neil Finlayson, Heather McEwan, Gillian E. Brown, Alistair Gorman, Andrey Gromov, Colin J. Campbell, Ahmet Erdogan, Robert K. Henderson, Gareth O. S. Williams

Author Affiliations +

Proceedings Volume 12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis; 1237302 (2023) https://doi.org/10.1117/12.2648899
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Time-resolved Raman and fluorescence lifetime spectroscopy imaging yields new research insights with great potential in applications including biomedical diagnostics, carbon materials, and battery development. Single Photon Avalanche Diode (SPAD) arrays are ideal for such applications and we present to our knowledge the first time-resolved Raman images obtained with such sensors. Utilizing motorized and confocal scanning configurations we obtain near shot-noise limited performance, room temperature operation, millisecond spectral acquisition times, and simultaneous acquisition and discrimination of Raman and fluorescence with high spectral resolution and range. Detailed images and spectra from samples including calcite, diamond, and single-wall carbon nanotubes demonstrate the possibility of high-resolution time-resolved Raman and fluorescence imaging.

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Citation Download Citation

Neil Finlayson, Heather McEwan, Gillian E. Brown, Alistair Gorman, Andrey Gromov, Colin J. Campbell, Ahmet Erdogan, Robert K. Henderson, and Gareth O. S. Williams "Time-correlated Raman imaging with a SPAD line sensor", Proc. SPIE 12373, Optical Biopsy XXI: Toward Real-Time Spectroscopic Imaging and Diagnosis, 1237302 (6 March 2023); https://doi.org/10.1117/12.2648899

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