Role of 5-HT receptors and transporters in psychiatric disorders

Jiayi Li

doi:10.1117/12.2668997

24 March 2023 Role of 5-HT receptors and transporters in psychiatric disorders

Jiayi Li

Proceedings Volume 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022); 126114S (2023) https://doi.org/10.1117/12.2668997
Event: International Conference on Biological Engineering and Medical Science (ICBioMed2022), 2022, Oxford, United Kingdom

Abstract

Serotonin, or 5-hydroxytryptamine (5-HT), a very important neurotransmitter that mediates various physiological and pathological functions, which are also dependent on its various types of receptors and transporters. However, also due to the diversity of the receptors and transporters, it is still tricky to define the role of serotonin clearly. In order to have a better understanding of serotonin’s role in psychiatric disorders and contributes to future research of therapeutic treatments to the mental disorders, this paper aims to review the role of 5-HT receptors and transporters in neuropsychiatric domains. 5-HT1A, 1B are the most studied serotonin receptors in depression and anxiety disorder. In addition, 5-HT2 and 5HT3 are involved in anxiety disorder, OCD, and also in schizophrenia. 5-HT6 and 5HT-7 receptors also might affect pathogenesis of schizophrenia. Given the complex pathogenesis of psychiatric disorders, serotonin may be less causal in causing the disorders especially depression, but they are still importantly involved in these disorders and the understanding of serotonin receptors is one of the keys to provide therapeutic treatment.

Citation Download Citation

Jiayi Li "Role of 5-HT receptors and transporters in psychiatric disorders", Proc. SPIE 12611, Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022), 126114S (24 March 2023); https://doi.org/10.1117/12.2668997

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