Differentiation of collagen-related skin diseases through polarimetry and fluorescence

Tsanislava I. Genova; Deyan D. Ivanov; Lidia B. Zaharieva; Victoria S. Mircheva; Tatiana Novikova; Razvigor Ossikovski; Petranka P. Troyanova

doi:10.1117/12.2670922

11 August 2023 Differentiation of collagen-related skin diseases through polarimetry and fluorescence

Tsanislava I. Genova, Deyan D. Ivanov, Lidia B. Zaharieva, Victoria S. Mircheva, Tatiana Novikova, Razvigor Ossikovski, Petranka P. Troyanova

Author Affiliations +

Proceedings Volume 12627, Translational Biophotonics: Diagnostics and Therapeutics III; 126272G (2023) https://doi.org/10.1117/12.2670922
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

Diagnosis of degenerative collagen-related skin diseases is a complex process that requires histopathological evaluation of various pathological alterations, which in addition are not unambiguous in themselves. Fluorescence spectroscopy has proven to be valuable tool for tissue differentiation, whereas the biomedical application of tissue polarimetry is establishing as a valuable diagnostic modality. In this work we present the evaluation of experimental results of histology tissue slides from three collagen-related skin diseases: psoriasis, lupus and scleroderma, through fluorescence spectroscopy and Muller polarimetry.

Citation Download Citation

Tsanislava I. Genova, Deyan D. Ivanov, Lidia B. Zaharieva, Victoria S. Mircheva, Tatiana Novikova, Razvigor Ossikovski, and Petranka P. Troyanova "Differentiation of collagen-related skin diseases through polarimetry and fluorescence", Proc. SPIE 12627, Translational Biophotonics: Diagnostics and Therapeutics III, 126272G (11 August 2023); https://doi.org/10.1117/12.2670922

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