Characterizing cell morphological changes based on deriving parameters from the Mueller matrix polarimetry

Shuan Yao; Nan Zeng; Hui Ma

doi:10.1117/12.2687150

27 November 2023 Characterizing cell morphological changes based on deriving parameters from the Mueller matrix polarimetry

Shuan Yao, Nan Zeng, Hui Ma

Author Affiliations +

Proceedings Volume 12770, Optics in Health Care and Biomedical Optics XIII; 127702F (2023) https://doi.org/10.1117/12.2687150
Event: SPIE/COS Photonics Asia, 2023, Beijing, China

Conference Poster

Abstract

In the clinic, certain diseases caused by genetic mutations or viral infections can alter the morphology and size of cells. Mueller matrix polarimetry is highly sensitive to microscale structural changes and can be utilized to detect cellular morphological alterations. Moreover, the extracting parameters from the Mueller matrix can serve as a key indicator for characterizing anomalous changes in cell morphology, demonstrating promising potential for application in disease analysis and diagnosis. Based on full polarization Mueller matrix imaging, this study proposes a characterization method for assessing red blood cell morphological changes induced by osmotic pressure. The results indicate significant variations in polarization parameters reflecting the morphological changes of red blood cells under different osmotic pressure regulations from sodium chloride solutions with different mass fractions. In addition, there are some differences in the sensitivity of different polarization parameters to cell deformation.

(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Shuan Yao, Nan Zeng, and Hui Ma "Characterizing cell morphological changes based on deriving parameters from the Mueller matrix polarimetry", Proc. SPIE 12770, Optics in Health Care and Biomedical Optics XIII, 127702F (27 November 2023); https://doi.org/10.1117/12.2687150

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