Mechanism of Qi-Jing-Sheng-Bai granule and leucogen in the treatment of leukopenia based on transcriptome

Yijie Liu

doi:10.1117/12.2692215

7 September 2023 Mechanism of Qi-Jing-Sheng-Bai granule and leucogen in the treatment of leukopenia based on transcriptome

Yijie Liu

Author Affiliations +

Proceedings Volume 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023); 127890P (2023) https://doi.org/10.1117/12.2692215
Event: International Conference on Modern Medicine and Global Health (ICMMGH 2023), 2023, Oxford, United Kingdom

Abstract

Traditional Chinese medicine compound preparation Qi-Jing-Sheng-Bai granule (QJSB) is used for the treatment of leukopenia. Its mechanism has not been discussed in depth in previous studies, so it is not clear at present. Leucogen is also a drug used to treat leukopenia, but its mechanism at the transcriptome level is not well understood. We find the mechanism of QJSB and Leucogen's transcriptome-based treatment of leukopenia, and the similarities and differences of mechanism between the two drugs in the treatment of leukopenia in this study. The result shows that both QJSB and Leucogen might regulate arachidonic acid metabolism pathway in the treatment of leukopenia. However, the molecular biological changes associated with the treatment of leukopenia with the two drugs are very different. QJSB may also treat leukopenia by regulating primary immunodeficiency, osteoclast differentiation, and TNF signaling pathway. Leucogen can also treat leukopenia by regulating oxidative phosphorylation and citrate cycle (TCA cycle). Through these studies, we can better understand the mechanism of QJSB and Leucogen in the treatment of leukopenia, which is very important for the clinical application of QJSB, and also provides help for the choice of drugs for different leukopenia patients.

Citation Download Citation

Yijie Liu "Mechanism of Qi-Jing-Sheng-Bai granule and leucogen in the treatment of leukopenia based on transcriptome", Proc. SPIE 12789, International Conference on Modern Medicine and Global Health (ICMMGH 2023), 127890P (7 September 2023); https://doi.org/10.1117/12.2692215

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